High‐frequency rTMS over the supplementary motor area for treatment of Parkinson's disease
Identifieur interne : 002811 ( Main/Exploration ); précédent : 002810; suivant : 002812High‐frequency rTMS over the supplementary motor area for treatment of Parkinson's disease
Auteurs : Masashi Hamada [Japon] ; Yoshikazu Ugawa [Japon] ; Sadatoshi Tsuji [Japon]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-08-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Analysis of Variance, Double-Blind Method, Female, High frequency, Humans, Male, Middle Aged, Motor Cortex (physiopathology), Motor Cortex (radiation effects), Nervous system diseases, Pain Measurement, Parkinson Disease (pathology), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Parkinson disease, Parkinson's disease, Repetitive stimulus, Severity of Illness Index, Supplementary motor area, Time Factors, Transcranial Magnetic Stimulation (methods), Transcranial magnetic stimulation, Treatment, repetitive transcranial magnetic stimulation, supplementary motor area.
- MESH :
- methods : Transcranial Magnetic Stimulation.
- pathology : Parkinson Disease.
- physiopathology : Motor Cortex, Parkinson Disease.
- radiation effects : Motor Cortex.
- therapy : Parkinson Disease.
- Adult, Aged, Aged, 80 and over, Analysis of Variance, Double-Blind Method, Female, Humans, Male, Middle Aged, Pain Measurement, Severity of Illness Index, Time Factors.
Abstract
Dysfunction of the basal ganglia‐thalamocortical motor circuit is a fundamental model to account for motor symptoms in Parkinson's disease (PD). Using high‐frequency repetitive transcranial magnetic stimulation (rTMS) over the supplementary motor area (SMA), we investigated whether modulation of SMA excitability engenders therapeutic effects on motor symptoms in PD. In this double‐blind placebo‐controlled study, 99 patients were enrolled and assigned randomly to SMA‐stimulation and sham‐stimulation groups. For SMA stimulation, 20 trains of 50 transcranial magnetic stimuli at 5 Hz were delivered at an intensity of 110% active motor threshold for leg muscles in one session. The sham stimulation was 20 trains of electric stimuli given through electrodes fixed on the head to mimic the cutaneous sensation during rTMS. Each session of intervention was carried out once a week for the first 8 weeks. The SMA stimulation, in contrast to the sham stimulation, engendered significant improvements in total scores and motor scores of the Unified Parkinson's Disease Rating Scale. Mean improvements in motor scores were 4.5 points in the SMA‐stimulation group and −0.1 points in the sham‐stimulation group. Results indicate that 5 Hz rTMS over SMA modestly improves motor symptoms in PD patients; SMA is a potential stimulation site for PD treatment. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22168
Affiliations:
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-08-15">2008-08-15</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1524">1524</biblScope><biblScope unit="page" to="1531">1531</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">C7CD7859628B7F0E6897A349ABC79363F670C6E1</idno><idno type="DOI">10.1002/mds.22168</idno><idno type="ArticleID">MDS22168</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Analysis of Variance</term><term>Double-Blind Method</term><term>Female</term><term>High frequency</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motor Cortex (physiopathology)</term><term>Motor Cortex (radiation effects)</term><term>Nervous system diseases</term><term>Pain Measurement</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Repetitive stimulus</term><term>Severity of Illness Index</term><term>Supplementary motor area</term><term>Time Factors</term><term>Transcranial Magnetic Stimulation (methods)</term><term>Transcranial magnetic stimulation</term><term>Treatment</term><term>repetitive transcranial magnetic stimulation</term><term>supplementary motor area</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Transcranial Magnetic Stimulation</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Motor Cortex</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Motor Cortex</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Analysis of Variance</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pain Measurement</term><term>Severity of Illness Index</term><term>Time Factors</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Aire motrice supplémentaire</term><term>Haute fréquence</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Stimulation magnétique transcrânienne</term><term>Stimulus répétitif</term><term>Traitement</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dysfunction of the basal ganglia‐thalamocortical motor circuit is a fundamental model to account for motor symptoms in Parkinson's disease (PD). Using high‐frequency repetitive transcranial magnetic stimulation (rTMS) over the supplementary motor area (SMA), we investigated whether modulation of SMA excitability engenders therapeutic effects on motor symptoms in PD. In this double‐blind placebo‐controlled study, 99 patients were enrolled and assigned randomly to SMA‐stimulation and sham‐stimulation groups. For SMA stimulation, 20 trains of 50 transcranial magnetic stimuli at 5 Hz were delivered at an intensity of 110% active motor threshold for leg muscles in one session. The sham stimulation was 20 trains of electric stimuli given through electrodes fixed on the head to mimic the cutaneous sensation during rTMS. Each session of intervention was carried out once a week for the first 8 weeks. The SMA stimulation, in contrast to the sham stimulation, engendered significant improvements in total scores and motor scores of the Unified Parkinson's Disease Rating Scale. Mean improvements in motor scores were 4.5 points in the SMA‐stimulation group and −0.1 points in the sham‐stimulation group. Results indicate that 5 Hz rTMS over SMA modestly improves motor symptoms in PD patients; SMA is a potential stimulation site for PD treatment. © 2008 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Japon</li></country><settlement><li>Tokyo</li></settlement></list><tree><country name="Japon"><noRegion><name sortKey="Hamada, Masashi" sort="Hamada, Masashi" uniqKey="Hamada M" first="Masashi" last="Hamada">Masashi Hamada</name></noRegion><name sortKey="Tsuji, Sadatoshi" sort="Tsuji, Sadatoshi" uniqKey="Tsuji S" first="Sadatoshi" last="Tsuji">Sadatoshi Tsuji</name><name sortKey="Ugawa, Yoshikazu" sort="Ugawa, Yoshikazu" uniqKey="Ugawa Y" first="Yoshikazu" last="Ugawa">Yoshikazu Ugawa</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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